Gentamicin also caused a significant decrease in BBM sphingomyelin, significant increases in BBM phosphatidylcholine and phosphatidylinositol, a significant decrease in the phospholipid fatty acid saturation index, and a signifi Physiology and Medical Physiology. Visualizing the regulation of SLC34 proteins at the apical membrane more. In this study, we investigated the effect of In this study, we investigated the effect of simultaneous inactivation of these bile acid receptors in atherosclerosis and which bile acid receptor mediates the anti-atherogenic effect of INT Lipid , Biochemistry and cell biology , and Medical biochemistry and metabolomics.
Intermittent fasting IF protects against the development of metabolic diseases and cancer, but whether it can prevent diabetic microvascular complications is not known.
We hypothesized that IF mediated changes in the gut microbiota would produce beneficial metabolites and prevent the development of DR. Consistent with the known modulatory effects of on bile acid BA metabolism, measurement of BAs demonstrated a si Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice more.
Increasingly, evidence suggests that exposure to maternal obesity creates an inflammatory environment, exerting long-lasting postnatal signatures on the juvenile innate immune system and microbiome that may predispose offspring to Increasingly, evidence suggests that exposure to maternal obesity creates an inflammatory environment, exerting long-lasting postnatal signatures on the juvenile innate immune system and microbiome that may predispose offspring to development of fatty liver disease.
We found that exposure to a maternal Western-style diet WD accelerated fibrogenesis in the liver of offspring and was associated with early recruitment of proinflammatory macrophages at weeks and microbial dysbiosis as early as 3 weeks of age. We further demonstrated that bone marrow-derived macrophages BMDMs were polarized toward an inflammatory state at 8 weeks of age and that a potent antioxidant, pyrroloquinoline quinone PQQ , reversed BMDM metabolic reprogramming from glycolytic toward oxidative metabolism by restoring trichloroacetic acid cycle function at isocitrate dehydrogenase.
This resulted in reduced inflammation and inhibited collagen fibril formation in the liver at 20 weeks of age, even when PQQ Obesity and obesity related kidney and liver disease have become more prevalent over the past few decades, especially in the western world.
Sodium-glucose cotransporter 2 SGLT2 inhibitors are a new class of antidiabetic agents with Sodium-glucose cotransporter 2 SGLT2 inhibitors are a new class of antidiabetic agents with promising effects on cardiovascular and renal function.
Given SGLT2 inhibitors exert both anti-diabetic and anti-obesity effects by promoting urinary excretion of glucose and subsequent caloric loss, we investigated the effect of the highly selective renal SGLT2 inhibitor dapagliflozin in mice with Western diet WD induced obesity. Dapagliflozin attenuated the WD-mediated increases in body weight, plasma glucose and plasma triglycerides. Treatment with dapagliflozin prevented podocyte injury, glomerular pathology and renal fibrosis determined by second harmonic generation SHG , nephrin, synaptopodin, collagen IV, and fibronectin immunofluorescence microscopy.
Erratum: Measuring the effect of Western diet on liver tissue architecture by FLIM autofluorescence and harmonic generation microscopy: erratum more. Publication Date: Publication Name: Biomedical optics express. There is very limited human renal sodium gradient dependent glucose transporter protein SGLT2 mRNA and protein expression data reported in the literature.
We have found that the expression of SGLT2 mRNA and protein is increased in renal biopsies from human subjects with diabetic nephropathy. This is in contrast to db-db mice which had no changes in renal SGLT-2 protein expression. Furthermore, the effect of SGLT2 inhibition on renal lipid content and inflammation is not known. Aim 2 of this study was to determine the potential mechanisms of beneficial effects of SGLT2 inhibition in progression of diabetic renal disease.
Internal Medicine. Partial LXR agonist reduces atherosclerosis in ApoE-deficient mice without inducing liver steatosis and hypertriglyceridemia more. Dynamic imaging of single microvilli in opossum kidney cells more. Regulation of phosphate transport by dietary Pi in the small intestine of rats Chronic kidney disease CKD increases bone fracture risk.
While the causes of bone fragility in CKD are not clear, the disrupted mineral homeostasis inherent to CKD may cause material quality changes to bone tissue.
In this study, Mice were fed a normal chow diet and euthanized 11weeks post-surgery. We compared nanoindentation modulus and mineral volume fraction assessed through quantitative backscattered scanning electron microscopy at matched sites in arrays placed on the cortical bone of the tibia mid-diaphysis.
We found that moderate CKD minimally affected bone microarchitecture and did not influence whole bone strength.
Meanwhile, bone material Microvillar protein trafficking and dynamics imaged by TIRF microscopy in living cells more. Differential regulation of NaPi2a and NaPi2c by parathyroid hormone more. Publication Name: Journal of Vascular Technology. Obesity and diabetes mellitus are the leading causes of renal disease.
Diabetic nephropathy—A multifaceted target of new therapies more. He has mentored more than 36 MD or PhD research trainees in his career. He says building strong relationships both externally, especially with NIH and Johns Hopkins University researchers, and across the Georgetown campus must be accomplished. What drives this engineer turned physician-researcher? Moshe Levi, MD. He accepts multiple insurance plans. Levi is board certified in Internal Medicine.
Click here to compare with other Nephrology Specialists. Find other locations and directions. Levi has not yet indicated whether they offer telehealth services. Find contact information here to make an appointment. Search Search. Moshe Levi, MD. Age 71 Nephrology M. Accepting New Patients. Show phone number Insurance Accepted. Patient Satisfaction.
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